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January 16, 2010 / dgiessman

Does Medical Research Have Fraud?

Scott S. Reuben, MD, former chief of the acute pain service at Baystate Medical Center in Springfield, Mass., and implicated in one of the largest cases of publishing fraud, has agreed to plead guilty to one charge of fraud in connection with falsifying and fabricating research studies involving Pfizer Inc.’s painkiller Celebrex.

Dr. Reuben is scheduled to appear in federal court on Feb. 22. As part of the agreement, Dr. Reuben will voluntarily enter into a disqualification agreement with the FDA. Debarred or disqualified investigators cannot engage in certain activities related to clinical research.

According to an Information document filed in the U.S. District Court of Massachusetts on Jan. 14, Dr. Reuben in September 2005 entered into a $73,512 clinical research grant agreement with Pfizer to compare Celebrex to placebo in 100 patients undergoing multimodal analgesia therapy. Dr. Reuben published articles in Anesthesia & Analgesia (2007;105:222-227 and 2007;105:228-232) claiming positive results in treating 200 patients with multimodal analgesia therapy, 100 with Celebrex and 100 with placebo. In fact, Dr. Reuben did not enroll any patients into that study and fabricated the results.

Dale Giessman, DC
350 John Muir Pkwy., Suite 265
Brentwood, CA 94513

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